KN-62

Overview

KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II ( CaMK-II ) with a K i of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X 7 receptors in HEK293 cells, with an IC 50 value of approximately 15 nM.

Application

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Product Information

• Catalog No.: HY-13290
• CAS No.: 127191-97-3
• Molecular Formula: C38H35N5O6S2
• Molecular Weight: 721.84
• Purity: 99.00%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution
• Availability: In-stock

Source

Original product source