M8891

Overview

M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC 50 of 54 nM and a K i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC 50 >10 µM). M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Signaling Pathways > MetAP

Product Information

• Catalog No.: HY-133016
• CAS No.: 1464842-09-8
• Molecular Formula: C20H17F2N3O3
• Molecular Weight: 385.36
• Purity: 99.69%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.08 mg/mL (5.40 mM); Clear solution
• Availability: In-stock

Source

Original product source