BML-260 is a potent inhibitor of dual-specific phosphatases JSP-1 and DUSP22 . BML-260 can activate UCP1 and thermogenesis in adipocytes in a JSP-1 -independent manner. The effect of BML-260 on adipocytes is partially achieved through the activation of CREB , STAT3 , and PPAR signaling pathways. BML-260 can be used in the research of inflammatory and proliferative disorders associated with JNK signaling dysfunction as well as obesity.
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