Tesevatinib tosylate

Overview

Tesevatinib (XL-647) tosylate is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor ( EGFR ). Tesevatinib tosylate significantly reduces cellular viability, with IC 50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib tosylate also inhibits HER2 ( IC 50 =16.1 nM), VEGFR2 ( IC 50 =1.5 nM), and Src ( IC 50 =10.3 nM). Tesevatinib tosylate can inhibit tumor proliferation and exhibits antitumor activity.

Application

Products | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Src

Product Information

• Catalog No.: HY-13314A
• CAS No.: 1000599-06-3
• Molecular Formula: C31H33Cl2FN4O5S
• Molecular Weight: 663.59
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source