PDD00017272

Overview

PDD00017272 is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) ( EC 50 =4.8 nM) and an activator of PARP1/2 . PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2 -dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC 50 of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Poly(ADP-ribose) Glycohydrolase (PARG)

Product Information

• Catalog No.: HY-133531
• CAS No.: 1945950-20-8
• Molecular Formula: C23H25N5O4S3
• Molecular Weight: 531.67
• Purity: 99.01%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (1.88 mM); Clear solution
• Availability: In-stock

Source

Original product source