AZD3839 fumarate

Overview

AZD3839 fumarate is an orally available, selective, reversible inhibitor of the β-site amyloid precursor protein cleaving enzyme BACE1 that can cross the blood-brain barrier. AZD3839 fumarate inhibits recombinant human BACE1 with a K i =26.1 nM. AZD3839 fumarate inhibits A40 production in SH-SY5Y cells with an IC 50 of 4.8 nM. AZD3839 fumarate binds to BACE1 and reduces the Aβ amyloid produced by the cleavage of amyloid precursor protein (APP) by BACE1 and γ-secretase . AZD3839 fumarate can be used in the field of Alzheimer's disease research .

Application

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Product Information

• Catalog No.: HY-13438A
• CAS No.: 1421852-78-9
• Molecular Formula: C28H20F3N5O4
• Molecular Weight: 547.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source