D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor ( IC 50 =48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties.
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