TNF-α-IN-2

Overview

TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα) , with an IC 50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis.

Application

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Product Information

• Catalog No.: HY-134471
• CAS No.: 2074702-04-6
• Molecular Formula: C25H21ClF2N6O
• Molecular Weight: 494.92
• Purity: 99.2%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (5.05 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source