WM-3835 is a potent and high-specific HBO1 ( KAT7 or MYST2 ) inhibitor and binds directly to the acetyl-CoA binding site of HBO1 . WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice.
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