GNF-5837

Overview

GNF-5837 is a potent, selective, and orally bioavailable pan- tropomyosin receptor kinase ( TRK ) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC 50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC , Tel-TrkB and Tel-TrkA , respectively) .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Pain | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-13491
• CAS No.: 1033769-28-6
• Molecular Formula: C28H21F4N5O2
• Molecular Weight: 535.49
• Purity: 99.44%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (4.67 mM); Clear solution
• Availability: In-stock

Source

Original product source