ML281

Overview

ML281 is a highly selective inhibitor of serine/threonine kinase 33 ( STK33 ) with an IC 50 value of 14 nM. ML281 shows 700-fold selectivity over PKA and 550-fold over AurB . ML281 exerts core mechanism by inhibiting STK33: in small cell lung cancer , ML281 downregulates RPS6/BAD signaling phosphorylation, induces apoptosis , and suppresses proliferation, invasion. ML281 reduces STK33-mediated 4-hydroxyphenylpyruvate dioxygenase ( HPD ) phosphorylation in tyrosinemia . ML281 is suitable for research on STK33 function, KRAS mutation-related cancers (pancreatic cancer , colon cancer , lung adenocarcinoma, etc.), small cell lung cancer , and tyrosinemia-related damage

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Amino Acid/Protein Metabolism | Products > Disease Areas > Small Cell Lung Cancer | Products > Disease Areas > Lung Adenocarcinoma | Products > Disease Areas > KRAS/Ras Mutation Colorectal Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > STK33 | Products > Signaling Pathways > PKA | Products > Signaling Pathways > Aurora Kinase

Product Information

• Catalog No.: HY-13495
• CAS No.: 1404437-62-2
• Molecular Formula: C22H19N3O2S
• Molecular Weight: 389.47
• Purity: 98.04%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Availability: In-stock

Source

Original product source