ACP-5862

Overview

ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC 50 of 5.0 nM for Bruton tyrosine kinase ( BTK ) . ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8 . Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor , with an IC 50 of 3 nM and EC 50 of 8 nM.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > Btk | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-135334
• CAS No.: 2230757-47-6
• Molecular Formula: C26H23N7O3
• Molecular Weight: 481.51
• Purity: 98.32%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution
• Availability: In-stock

Source

Original product source