JMS-053

Overview

JMS-053 is an efficient and reversible PTP4A3 inhibitor, with an IC 50 value of 18 nM. JMS-053 demonstrates broad PTP4A inhibitory activity with IC 50 s of 50 nM and 53 nM for PTP4A1 and PTP4A2 , respectively. JMS-053 exhibits IC 50 values of 92.6 nM and 207.6 nM for CDC25B and DUSP3 , respectively. JMS-053 can effectively inhibit the activity of PTP4A3, inhibit tumor cell proliferation and migration through multiple mechanisms such as interfering with RhoA and STAT3/p38 signaling pathway. JMS-053 can be used for the study of cancers such as ovarian cancer , breast cancer and colon cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-135457
• CAS No.: 1954650-11-3
• Molecular Formula: C13H8N2O2S
• Molecular Weight: 256.28
• Purity: 98.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 1 mg/mL (3.90 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source