Rencofilstat

Overview

Rencofilstat (CRV431) is an orally active pan- cyclophilin inhibitor with IC 50 values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease. Rencofilstat can be used for the study of nonalcoholic steatohepatitis (NASH), hepatocellular carcinoma and viral hepatitis-induced liver disease.

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Cyclophilin | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Nuclear Factor of activated T Cells (NFAT) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-135644
• CAS No.: 1383420-08-3
• Molecular Formula: C67H122N12O13
• Molecular Weight: 1303.76
• Purity: 90.29%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (1.92 mM); Clear solution
• Availability: In-stock

Source

Original product source