Bavarostat

Overview

Bavarostat (EKZ-001) is a blood-brain barrier-permeable, potent HDAC6 inhibitor and PET radiotracer, with an IC 50 as low as 17 nM against human HDAC6 . Bavarostat can be labeled with 18 F and used as a probe to map HDAC6 distribution and measure target occupancy in the brains of non-human primates. Bavarostat also selectively modulates tubulin acetylation, but not histone acetylation. Bavarostat is applicable for research on Alzheimer's disease, other neurodegenerative disorders, and cancers.

Application

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Product Information

• Catalog No.: HY-135714
• CAS No.: 2134109-20-7
• Molecular Formula: C20H27FN2O2
• Molecular Weight: 346.44
• Purity: 99.51%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution
• Availability: In-stock

Source

Original product source