OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K + channels and has Ca 2+ -sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis , cardiac remodeling and myocardial inflammation.
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