BO-264

Overview

BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC 50 of 188 nM and a K d of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis . BO-264 has broad-spectrum antitumor activity.

Application

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Product Information

• Catalog No.: HY-135960
• CAS No.: 2408648-20-2
• Molecular Formula: C18H19N5O3
• Molecular Weight: 353.38
• Purity: 99.76%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (5.89 mM); Clear solution
• Availability: In-stock

Source

Original product source