MI-3454

Overview

MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC 50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1 -rearranged or NPM1 -mutated leukemia through downregulation of key genes involved in leukemogenesis.

Application

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Product Information

• Catalog No.: HY-136360
• CAS No.: 2134169-43-8
• Molecular Formula: C32H35F3N8OS
• Molecular Weight: 636.73
• Purity: 98.03%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)
• Solubility: 5 mg/mL (7.85 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source