BAY-876

Overview

BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 ( GLUT1 ) inhibitor with an IC 50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2 , GLUT3 , and GLUT4 . BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .

Application

Products | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > GLUT | Products > Signaling Pathways > Disulfidptosis

Product Information

• Catalog No.: HY-100017
• CAS No.: 1799753-84-6
• Molecular Formula: C24H16F4N6O2
• Molecular Weight: 496.42
• Purity: 99.67%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution
• Availability: In-stock

Source

Original product source