IRE1α kinase-IN-1

Overview

IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC 50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC 50 =80 nM).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > IRE1

Product Information

• Catalog No.: HY-136735
• CAS No.: 2328097-41-0
• Molecular Formula: C26H26ClFN8
• Molecular Weight: 504.99
• Purity: 98.94%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution
• Availability: In-stock

Source

Original product source