PI3K-IN-11

Overview

PI3K-IN-11 (compound 13) is a PI3K inhibitor, which selectively inhibits PI3Kα , PI3Kβ , PI3K , and PI3Kδ ( IC 50 s=6.4, 13, 8, and 11 nM, respectively) over mTOR ( IC 50 =2.9 μM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 μg/mL. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.

Application

Products | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K

Product Information

• Catalog No.: HY-136765
• CAS No.: 884539-95-1
• Molecular Formula: C29H42N2O8
• Molecular Weight: 546.65
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source