PQ401

Overview

PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC 50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC 50 , 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis .

Application

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Product Information

• Catalog No.: HY-13686
• CAS No.: 196868-63-0
• Molecular Formula: C18H16ClN3O2
• Molecular Weight: 341.79
• Purity: 99.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1.43 mg/mL (4.18 mM); Clear solution
• Availability: In-stock

Source

Original product source