IKK 16

Overview

IKK 16 is an orally active IKK inhibitor . IKK 16 shows IC 50 s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1 , PKD2 , and PKD3 with IC 50 s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS ( HY-D1056 )-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.

Application

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Product Information

• Catalog No.: HY-13687
• CAS No.: 873225-46-8
• Molecular Formula: C28H29N5OS
• Molecular Weight: 483.63
• Purity: 99.88%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution
• Availability: In-stock

Source

Original product source