IKK 16 hydrochloride

Overview

IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC 50 s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2 , IKK complex, IKK1 , and LRRK 2 , respectively. IKK 16 hydrochloride is also a pan- PKD inhibitor, inhibiting PKD1 , PKD2 , and PKD3 with IC 50 s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS ( HY-D1056 )-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.

Application

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Product Information

• Catalog No.: HY-13687A
• CAS No.: 1186195-62-9
• Molecular Formula: C28H30ClN5OS
• Molecular Weight: 520.09
• Purity: 99.95%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (4.81 mM); Clear solution
• Availability: In-stock

Source

Original product source