NSC 663284

Overview

NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC 50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 ( IC 50 of 170 nM) through a direct interaction with the catalytic SET domain ( K d of 370 nM).

Application

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Product Information

• Catalog No.: HY-100034
• CAS No.: 383907-43-5
• Molecular Formula: C15H16ClN3O3
• Molecular Weight: 321.76
• Purity: 99.29%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (7.77 mM); Clear solution
• Availability: In-stock

Source

Original product source