USP7-797

Overview

USP7-797 (USP7-IN-7) is an orally available, selective USP7 inhibitor ( IC 50 =0.5 nmol/L) with antitumor activity. USP7-797 reduces the level of MDM2 , thereby increasing the stability and activity of p53 , leading to cell cycle arrest and apoptosis . USP7-797 has low nanomolar cytotoxicity against p53 mutant cancer cell lines, p53 wild-type hematological tumors, and neuroblastoma cell lines.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase | Products > Signaling Pathways > MDM-2/p53

Product Information

• Catalog No.: HY-136910
• CAS No.: 2413944-70-2
• Molecular Formula: C27H28ClN3O3S
• Molecular Weight: 510.05
• Purity: 99.09%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 3.75 mg/mL (7.35 mM); Clear solution
• Availability: In-stock

Source

Original product source