IACS-13909

Overview

IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC 50 of 15.7 nM and a K d of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SHP2 | Products > Signaling Pathways > Phosphatase

Product Information

• Catalog No.: HY-137092
• CAS No.: 2160546-07-4
• Molecular Formula: C17H18Cl2N6
• Molecular Weight: 377.27
• Purity: 99.97%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (2.65 mM); Clear solution
• Availability: In-stock

Source

Original product source