DTHIB

Overview

DTHIB is a direct and selective heat shock factor 1 ( HSF1 ) inhibitor with a K d of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD) . DTHIB inhibits HSF1 cancer gene signature ( HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1 . DTHIB has potently anticancer activities and can be used for prostate cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-138280
• CAS No.: 897326-30-6
• Molecular Formula: C13H9ClFN3O3
• Molecular Weight: 309.68
• Purity: 99.82%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 2.08 mg/mL (6.72 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source