SY-5609

Overview

SY-5609 (CDK7-IN-3) is an orally active, highly selective, noncovalent CDK7 inhibitor with a K D of 0.065 nM. SY-5609 shows poor inhibition on CDK2 (K i =2600 nM), CDK9 (K i =960 nM), CDK12 (K i =870 nM). SY-5609 induces apoptosis in tumor cells and has antitumor activity.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-138293
• CAS No.: 2417302-07-7
• Molecular Formula: C23H26F3N6OP
• Molecular Weight: 490.46
• Purity: 99.93%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution
• Availability: In-stock

Source

Original product source