K-975

Overview

K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD . K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma.

Application

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Product Information

• Catalog No.: HY-138565
• CAS No.: 2563855-03-6
• Molecular Formula: C16H14ClNO2
• Molecular Weight: 287.74
• Purity: 99.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 5.5 mg/mL (19.11 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source