Ro 31-8220 mesylate

Overview

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC 50 s of 5, 24, 14, 27, 24 and 23 nM for PKCα , PKCβI, PKCβII, PKCγ , PKCε and rat brain PKC , respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β ( IC 50 s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun , and activate JNK , and these effects possess pharmacological properties independent of PKC .

Application

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Product Information

• Catalog No.: HY-13866
• CAS No.: 138489-18-6
• Molecular Formula: C26H27N5O5S2
• Molecular Weight: 553.65
• Purity: 99.57%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (3.76 mM); Clear solution
• Availability: In-stock

Source

Original product source