BM-1244

Overview

BM-1244 (APG-1252-M1) is a Bcl-xL / Bcl-2 inhibitor with K i s of 134 nM and 450 nM. BM-1244 has anti-tumor effects by inducing apoptosis and suppressing tumor growth. BM-1244 can induce cytochrome C and Smac release from mitochondria with caspase-3 and PARP cleavage. BM-1244 exhibits synergy with chemotherapy in vivo. BM-1244 can be studied in research for colorectal cancer , acute myeloid leukemia and gastric cancer .

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-138832
• CAS No.: 1619923-32-8
• Molecular Formula: C54H59ClF4N6O8S4
• Molecular Weight: 1159.79
• Purity: 99.83%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 5 mg/mL (4.31 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source