NNMT-IN-6 is a selective nicotinamide N-methyltransferase ( NNMT ) inhibitor with an IC 50 of 1.41 μM and a K d of 5.55 μM. NNMT-IN-6 hydrochloride exhibits selectivity over PRMT1 and NSD2 . NNMT-IN-6 inhibits cancer cell proliferation and reduces cellular N-methylnicotinamide (MNA) production. NNMT-IN-6 can be used for the research of oral cancer .
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