IWP-2

Overview

IWP-2 is an inhibitor of Wnt processing and secretion with an IC 50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC 50 of 40 nM for the gatekeeper mutant M82F CK1δ .

Application

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Product Information

• Catalog No.: HY-13912
• CAS No.: 686770-61-6
• Molecular Formula: C22H18N4O2S3
• Molecular Weight: 466.60
• Purity: 99.93%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 0.2 mg/mL (0.43 mM); Clear solution
• Availability: In-stock

Source

Original product source