Simufilam hydrochloride

Overview

Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. Simufilam hydrochloride restores NMDAR signaling and Arc expression. Simufilam hydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ 42 -induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride can be used for research of Alzheimer's disease.

Application

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Product Information

• Catalog No.: HY-139142B
• CAS No.: 2480226-07-9
• Molecular Formula: C15H22ClN3O
• Molecular Weight: 295.81
• Purity: 99.85%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (8.45 mM); Clear solution
• Availability: In-stock

Source

Original product source