Indirubin-3′-oxime

Overview

Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β) . Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK ( JNK1 , JNK2 , and JNK3 ), with IC 50 s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes.

Application

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Product Information

• Catalog No.: HY-139254
• CAS No.: 667463-82-3
• Molecular Formula: C16H11N3O2
• Molecular Weight: 277.28
• Purity: 99.10%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (9.02 mM); Clear solution
• Availability: In-stock

Source

Original product source