Zotizalkib

Overview

Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK ( IC 50 of 1.4 nM) and ALK-resistant mutation , e.g. G1202R ( IC 50 of 0.3 nM), L1196M ( IC 50 of 0.3 nM). Zotizalkib has strong antitumor activities.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK)

Product Information

• Catalog No.: HY-139279
• CAS No.: 2648641-36-3
• Molecular Formula: C21H20F3N5O3
• Molecular Weight: 447.41
• Purity: 98.02%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.65 mM); Clear solution
• Availability: In-stock

Source

Original product source