CDK12-IN-5

Overview

CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC 50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC 50 =173 μM) and CDK9/Cyclin T1 (IC 50 =127 μM) at high ATP (2 mM) (WO2021116178A1).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-139328
• CAS No.: 2651200-35-8
• Molecular Formula: C18H15F5N8O
• Molecular Weight: 454.36
• Purity: 98.03%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.08 mg/mL (4.58 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source