ARI-1

Overview

ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 ( ROR1 ) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and p-P38 . ARI-1 induces Apoptosis . ARI-1 has anticancer activity against non-small cell lung cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > PARP | Products > Signaling Pathways > ROR | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-139534
• CAS No.: 3078120-01-8
• Molecular Formula: C20H22O7
• Molecular Weight: 374.38
• Purity: 99.16%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (6.68 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source