PCC0208017

Overview

PCC0208017 is a microtubule affinity regulating kinases ( MARK3/MARK4 ) inhibitor with IC 50 s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC 50 s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis . PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability.

Application

Products | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MARK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-139604
• CAS No.: 2623158-64-3
• Molecular Formula: C19H20F3N7
• Molecular Weight: 403.40
• Purity: 99.52%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (12.39 mM); Clear solution
• Availability: In-stock

Source

Original product source