Sec61-IN-3

Overview

Sec61-IN-3 is a Sec61 inhibitor. Sec61-IN-3 shows a significant inhibitory effect on PD-1 related reporter gene cell models (PD1tsGluc) (IC 50 = 42 nM), and also has certain inhibitory activity on Her3 (IC 50 = 99 nM), IL2 (IC 50 = 144 nM) related reporter pathways, but has a relatively weak inhibitory effect on the TNFα (IC 50 = 580 nM) pathway. Sec61-IN-3 can be used for cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Sec61 | Products > Signaling Pathways > PD-1/PD-L1 | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-139617
• CAS No.: 2484862-54-4
• Molecular Formula: C25H26N4O2S
• Molecular Weight: 446.56
• Purity: 99.22%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (5.60 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source