SC13 is an orally active, selective Flap structure-specific endonuclease 1 ( FEN1 ) inhibitor and mu opioid receptor ( MOR ) activator. SC13 impairs DNA damage repair and induces apoptosis in cancer cells. SC13 activates cGAS-STING signaling, increases chemokine secretion, and promotes CAR-T cell infiltration at solid tumour sites. SC13 can be used for the research of solid tumours and pain.
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