Epyrifenacil is a protoporphyrinogen oxidase ( PPO ) inhibiting herbicide , potently targeting the PPO 2 isoform from weeds such as Amaranthus palmeri with an IC 50 of 0.637 nM. Epyrifenacil also inhibits liver mitochondrial PPO across species, with IC 50 values of 2.2 nM (mouse), 2.6 nM (rat), 12.1 nM (rabbit), 7.6 nM (dog), and 10.2 nM (human). Epyrifenacil induces liver tumor development in mice. Epyrifenacil can be used for weed control, and also used as a tool compound in toxicological research to study the mechanism of PPO inhibition, chemical-induced hepatotoxicity, and the mode of action of non-genotoxic carcinogens in rodents [3] .
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