NT-1

Overview

NT-1 ( EGFR mutant-IN-3) is a potent mutant EGFR inhibitor and an analog of Osimertinib ( HY-15772 ). This mutant EGFR inhibitor suppresses FGFR WT with an IC 50 of 0.4 nM. NT-1 also inhibits EGFR L858R , EGFR Exon 19 deletion and EGFR T790M . NT-1 exerts deeper inhibition on p-EGFR and p-ERK , and induces tumor cell apoptosis . NT-1 can be used in colorectal cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Others | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-13984
• CAS No.: 1421373-62-7
• Molecular Formula: C27H30ClN7O2
• Molecular Weight: 520.03
• Purity: 99.40%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (4.81 mM); Clear solution
• Availability: In-stock

Source

Original product source