ART558

Overview

ART558 is a potent, selective and allosteric DNA polymerase theta (Polθ) inhibitor ( IC 50 =7.9 nM). ART558 elicits BRCA-gene synthetic lethality and DNA damage. ART558 can be used for the research of cancer , such as breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-141520
• CAS No.: 2603528-97-6
• Molecular Formula: C21H21F3N4O2
• Molecular Weight: 418.41
• Purity: 99.75%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)
• Solubility: ≥ 5 mg/mL (11.95 mM); Clear solution
• Availability: In-stock

Source

Original product source