MRK-560

Overview

MRK-560, a chemical probe, is an orally active, brain barrier-penetrated γ-Secretase inhibitor, reducing Aβ peptide in rat brain and cerebrospinal fluid. MRK-560 decreases mutant NOTCH1 processing by selectively inhibiting PSEN1 . MRK-560 can be used in studies of Alzheimer's disease and T-cell acute lymphoblastic leukaemia (T-ALL).

Application

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Product Information

• Catalog No.: HY-14174
• CAS No.: 677772-84-8
• Molecular Formula: C19H17ClF5NO4S2
• Molecular Weight: 517.92
• Purity: 99.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution
• Availability: In-stock

Source

Original product source