STF-1084

Overview

STF-1084 is a specific, cell-impermeable, competitive inhibitor of ENPP1 ( K i = 33 nM). STF-1084 increases extracellular cGAMP concentrations by preventing its degradation by ENPP1 , thereby enhancing immune infiltration. STF-1084 acts synergistically with ionizing radiation (IR) and cGAMP to delay tumor progression. STF-1084 can be used to study cancers with low immunogenicity.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Phosphodiesterase (PDE)

Product Information

• Catalog No.: HY-141831
• CAS No.: 2298390-71-1
• Molecular Formula: C17H24N3O5P
• Molecular Weight: 381.36
• Purity: 99.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.2 mg/mL (3.15 mM); Clear solution
• Availability: In-stock

Source

Original product source