GNE-9815

Overview

GNE-9815 (compound 7) is a highly selective, pan- RAF inhibitor with good oral bioavailability. GNE-9815 exhibits K i values of 0.062 and 0.19 nM for CRAF and BRAF , respectively. GNE-9815 combines with MEK inhibitor Cobimetinib ( HY-13064 ) shows synergistic modulation of MAPK pathway. GNE-9815 can be used in studies of KRAS mutant cancers.

Application

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Product Information

• Catalog No.: HY-142160
• CAS No.: 2729996-45-4
• Molecular Formula: C26H22FN5O2
• Molecular Weight: 455.48
• Purity: 98.94%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.49 mM); Clear solution
• Availability: In-stock

Source

Original product source