Siramesine

Overview

Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors ( IC 50 =0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors ( IC 50 =17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.

Application

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Product Information

• Catalog No.: HY-14221
• CAS No.: 147817-50-3
• Molecular Formula: C30H31FN2O
• Molecular Weight: 454.58
• Purity: 98.98%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source