Siramesine hydrochloride

Overview

Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors ( IC 50 =0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors ( IC 50 =17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.

Application

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Product Information

• Catalog No.: HY-14221A
• CAS No.: 224177-60-0
• Molecular Formula: C30H32ClFN2O
• Molecular Weight: 491.04
• Purity: 99.69%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution
• Availability: In-stock

Source

Original product source